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. 2016 Feb 14;84(1):167-79.
doi: 10.3797/scipharm.ISP.2015.08. Print 2016 Jan-Mar.

Prevalence of Adverse Drug Reactions in CAD STEMI Patients Treated in the Cardiac Intensive Care Unit at the Public Hospital in Bandung, Indonesia

Lia Amalia  1 , Kusnandar Anggadireja  1 , Toni M Aprami  2 , Vina Septiani  1
Affiliations

Prevalence of Adverse Drug Reactions in CAD STEMI Patients Treated in the Cardiac Intensive Care Unit at the Public Hospital in Bandung, Indonesia

Lia Amalia et al. Sci Pharm. .

Abstract

Adverse drug reactions (ADRs) are associated with morbidity, mortality, and can contribute to increased healthcare costs. This study was conducted to identify the occurence, types, and management of ADRs, as well as analyze the causal relationship, severity, and preventability of ADRs. The study was observational analysis with concurrent data collection from patients with Coronary Artery Disease-ST segment Elevation Myocardial Infarction (CAD-STEMI) treated in the Cardiac Intensive Care Unit (CICU) at a hospital in Bandung Indonesia, during the period of December 2013 to March 2014. The occurence of identified ADRs was assessed using the probability scale of Naranjo, while the severity by the scale of Hartwig and their preventability was evaluated using the scale of Schumock-Thornton. 49 ADRs were identified in 29 patients. Organ systems most affected by the ADRs were the cardiovascular and body electrolyte, each accounting for 20.41%. The hematology and gastrointestinal systems each contributed 18.37% to ADR occurrences. The causal relationship was mostly classified as "probable," accounting for 69.39%. With regard to severity, most ADRs were classified as "moderate" at level 3, contributing to 53.06% of the occurence. In terms of preventability, most of the ADRs fell into the "non-preventable" category (79.59%). The most widely applied ADRs management was administration of an antidote or other treatments (40.82%). Further analysis revealed that the average number of drug types and duration of hospitalization significantly affected the presence of ADRs. Taken together, most patients with CAD STEMI treated in the CICU of the studied hospital experienced non-preventable ADRs and were treated with antidote or other treatments.

Keywords: ADRs; CAD STEMI; Hartwig; Naranjo; Schumock-Thornton scales.

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Figures

Fig. 1
Fig. 1
Distribution profile of CAD STEMI patients based on gender and age groups
Fig. 2
Fig. 2
Profile of smoking history of CAD STEMI patients
Fig. 3
Fig. 3
Profile of Distribution profile of patients with secondary diagnosis in CAD STEMI patients
Fig. 4
Fig. 4
Profile of secondary diagnosis in CAD STEMI patients
Fig. 5
Fig. 5
Profile of number of ADRs experienced by patients with CAD STEMI
See this image and copyright information in PMC

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