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Review
. 2016 Jun;16(6):53.
doi: 10.1007/s11892-016-0738-2.

Islet Autoantibodies

Vito Lampasona  1   2 , Daniela Liberati  3   4
Affiliations
Review

Islet Autoantibodies

Vito Lampasona et al. Curr Diab Rep. 2016 Jun.

Abstract

Islet autoantibodies are the main markers of pancreatic autoimmunity in type 1 diabetes (T1D). Islet autoantibodies recognize insulin (IAA), glutamic acid decarboxylase (GADA), protein phosphatase-like IA-2 (IA-2A), and ZnT8 (ZnT8A), all antigens that are found on secretory granules within pancreatic beta cells. Islet antibodies, measured by sensitive and specific liquid phase assays, are the key parameters of the autoimmune response monitored for diagnostics or prognostics in patients with T1D or for disease prediction in at-risk individuals before T1D onset. Islet autoantibodies have been the main tool used to explore the natural history of T1D; this review summarizes the current knowledge about the autoantigens and the phenotype of islets autoantibodies acquired in large prospective studies from birth in children at risk of developing T1D.

Keywords: Autoantibodies; GAD65; IA-2; Insulin; T1D; ZnT8.

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References

    1. Lancet. 1974 Nov 30;2(7892):1279-83 - PubMed
    1. Diabetes. 2015 Sep;64(9):3239-46 - PubMed
    1. Diabetes. 1996 Apr;45(4):496-501 - PubMed
    1. Clin Immunol. 2007 Nov;125(2):120-6 - PubMed
    1. Clin Exp Immunol. 2014 Sep;177(3):571-85 - PubMed

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