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. 2016 Apr 26:12:18.
doi: 10.1186/s13005-016-0115-z.

Oral lichen planus clinical characteristics in Italian patients: a retrospective analysis

Dorina Lauritano  1 , Mariantonietta Arrica  2 , Alberta Lucchese  3 , Marina Valente  4 , Giuseppe Pannone  4 , Carlo Lajolo  5 , Rossella Ninivaggi  6 , Massimo Petruzzi  7
Affiliations

Oral lichen planus clinical characteristics in Italian patients: a retrospective analysis

Dorina Lauritano et al. Head Face Med. .

Abstract

Background: Oral lichen Planus (OLP) is a chronic inflammatory disease involving skin and mucous membranes. Its etiology is still uncertain whilst an autoimmune mechanism is known to be implicated. OLP is commonly considered a geriatric disease and gender differences in prevalence are clear, whereby females are generally more frequently affected than males more often during the 5th and 6th decades of life. Lesions are symmetrical and bilateral and the buccal mucosa is frequently involved. The risk of malignant transformation is extremely low. This study aims to describe both the clinical characteristics and the prevalence of OLP among a group of patients from Southern Italy. The results of the present study were compared to analogous retrospective studies.

Methods: Eighty-seven (31 man and 56 woman) cases of OLP were retrospectively reviewed and demographic and clinical data were collected. Data about OLP as clinical forms, oral and extraoral sites involved and Visual Analogue Scale were also recorded.

Results: The average age of OLP onset was 59.2 years. The most common clinical presentation was the hyperkeratosic type. Symptomatic OLP was noted in 26.8 % of the patiens. The most frequently affected oral sites were buccal mucosa, tongue, gums. The most frequently associated systemic diseases were diabetes, hypertension, C hepatitis and thyroiditis. Only one patient developed a malignant transformation (1.2 %).

Conclusions: Previous retrospective studies report data partially comparable with our results. Different geographic area, number of enrolled patients and OLP classification criteria may justify the observed differences.

Keywords: Autoimmune diseases; Oral lichen planus; Retrospective study.

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Figures

Fig. 1
Fig. 1
Classical clinical aspect of a reticular oral lichen planus
Fig. 2
Fig. 2
Hyperkeratotic OLP showing hyperkeratosis, bandlike monomorphic lymphocytic infiltrate, liquefactive degeneration of basal epithelial cells creating small Max Joseph spaces (H&E, original magnification x10)
Fig. 3
Fig. 3
Erosive OLP involving the buccal mucosa. A pseudomembrane cover the erosive area
Fig. 4
Fig. 4
Erosive area in OLP (H&E, original magnification x10)
See this image and copyright information in PMC

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References

    1. Baccaglini L, Thongprasom K, Carrozzo M, Bigby M. Urban legends series: lichen planus. Oral Dis. 2013;19(2):128–43. doi: 10.1111/j.1601-0825.2012.01953.x. - DOI - PubMed
    1. McCartan BE, Healy CM. the reported prevalence of oral lichen planus: a rewiew and critique. J Oral Pathol Med. 2008;37(8):447–53. doi: 10.1111/j.1600-0714.2008.00662.x. - DOI - PubMed
    1. Di Stasio D, Guida A, Salerno C, Contaldo M, Esposito V, Laino L, Serpico R, Lucchese A. Oral lichen planus: a narrative review. Front Biosci (Elite Ed) 2014;6:370–6. doi: 10.2741/712. - DOI - PubMed
    1. Payeras MR, Cherubini K, Figueiredo MA, Salum FG. Oral lichen planus: focus on etiopathogenesis. Arch Oral Biol. 2013;58(9):1057–69. doi: 10.1016/j.archoralbio.2013.04.004. - DOI - PubMed
    1. Gupta S, Jawanda MK. Oral Lichen Planus: An Update on Etiology, Pathogenesis, Clinical Presentation,Diagnosis and Management. Indian J Dermatol. 2015;60(3):222–9. doi: 10.4103/0019-5154.156315. - DOI - PMC - PubMed

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