Review
doi: 10.1007/s10495-016-1244-3.
Clinical and pathological significance of N-Myc downstream-regulated gene 2 (NDRG2) in diverse human cancers
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- PMID: 27113371
- DOI: 10.1007/s10495-016-1244-3
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Review
Clinical and pathological significance of N-Myc downstream-regulated gene 2 (NDRG2) in diverse human cancers
Apoptosis.
2016 Jun.
Abstract
Human N-Myc downstream-regulated gene 2 (NDRG2), located at chromosome 14q11.2, has been reported to be down-regulated and associated with the progression and prognosis of diverse cancers. Collectively, previous studies suggest that NDRG2 functions as a candidate tumor-suppressor gene; thus, up-regulation of NDRG2 protein might act as a promising therapeutic strategy for malignant tumors. The aim of this review was to comprehensively present the clinical and pathological significance of NDRG2 in human cancers.
Keywords: Cancers; Clinical and pathological significance; N-Myc downstream-regulated gene 2.
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