Case Reports
doi: 10.1002/ijc.2910200608.
Further evidence for a non-random chromosomal abnormality in acute promyelocytic leukemia
- PMID: 271143
- DOI: 10.1002/ijc.2910200608
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Case Reports
Further evidence for a non-random chromosomal abnormality in acute promyelocytic leukemia
Int J Cancer.
.
Abstract
We have previously reported on two patients with acute promyelocytic leukemia (APL) who had what appeared to be a deletion of chromosome No. 17. We now describe a third patient with APL. All three patients had a structural rearrangement involving No. 15 and No. 17. Our current interpretation of the chromosomal abnormality is that it is a reciprocal translocation, t (15;17) (q22; q21). Evidence that this is a consistent rearrangement associated with APL comes not only from our three patients, but also from two other published cases of APL, studied with banding, who also had an identical abnormality.
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