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Comment
. 2016 Apr 25;26(8):R329-31.
doi: 10.1016/j.cub.2016.02.059.

Oogenesis: Ageing Oocyte Chromosomes Rely on Amazing Protein Stability

Attila Toth  1 , Rolf Jessberger  2
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Oogenesis: Ageing Oocyte Chromosomes Rely on Amazing Protein Stability

Attila Toth et al. Curr Biol. .
Free article

Abstract

Meiotic chromosome segregation in mouse oocytes seems to rely on highly stable cohesins and CENP-A produced in the fetus and not replenished during postnatal life. Hence, demise of these proteins may underpin declining oocyte quality in ageing mammals and thus marks a major problem of reproductive health in humans.

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