Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 Nov;31(6):1018-1029.
doi: 10.3904/kjim.2015.224. Epub 2016 Apr 27.

Vitamin D and its effects on cardiovascular diseases: a comprehensive review

Nonanzit Pérez-Hernández  1 , Gad Aptilon-Duque  1   2 , María Cristina Nostroza-Hernández  1 , Gilberto Vargas-Alarcón  1 , José Manuel Rodríguez-Pérez  1 , Ruben Blachman-Braun  1   2
Affiliations
Review

Vitamin D and its effects on cardiovascular diseases: a comprehensive review

Nonanzit Pérez-Hernández et al. Korean J Intern Med. 2016 Nov.

Abstract

Vitamin D is a molecule that is actively involved in multiple metabolic pathways. It is mostly known for its implications related to calcium metabolism. It has also been determined that it actively participates in the cardiovascular system, influencing blood pressure, coronary artery disease and other vascular diseases, such as heart failure and atrial fibrillation. Furthermore, it has been established that this vitamin is extensively involved in the regulation of both the renin angiotensin aldosterone system and the immune system. In this review, we present the different vitamin D metabolic pathways associated with the cardiovascular pathophysiology, and we include studies in animal and human models, as well as some of the controversies found in the literature. This review also incorporates an overview of the implications in the molecular biology and public health fields.

Keywords: Cardiovascular system; Metabolic networks and pathways; Vitamin D.

PubMed Disclaimer

Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

Figures

Figure 1.
Figure 1.
Schematic representation of vitamin D metabolism. UVB, ultraviolet B; 25 (OH)D3, 25-hydroxyvitamin D.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Wacker M, Holick MF. Sunlight and vitamin D: a global perspective for health. Dermatoendocrinol. 2013;5:51–108. - PMC - PubMed
    1. Holick MF, Chen TC. Vitamin D deficiency: a worldwide problem with health consequences. Am J Clin Nutr. 2008;87:1080S–1086S. - PubMed
    1. Morris HA. Vitamin D activities for health outcomes. Ann Lab Med. 2014;34:181–186. - PMC - PubMed
    1. Parker J, Hashmi O, Dutton D, et al. Levels of vitamin D and cardiometabolic disorders: systematic review and meta-analysis. Maturitas. 2010;65:225–236. - PubMed
    1. Lappe JM, Travers-Gustafson D, Davies KM, Recker RR, Heaney RP. Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial. Am J Clin Nutr. 2007;85:1586–1591. - PubMed

MeSH terms

LinkOut - more resources