Directing lipid transport at membrane contact sites
- PMID: 27117329
- DOI: 10.1038/ncb3345
Directing lipid transport at membrane contact sites
Abstract
Contact sites between the endoplasmic reticulum and the plasma membrane mediate receptor signalling. How this function is controlled physically and functionally is poorly understood. Extended synaptotagmins are now shown to shuttle the lipid metabolite diacylglycerol from the plasma membrane to the endoplasmic reticulum in receptor-stimulated cells.
Comment on
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Control of plasma membrane lipid homeostasis by the extended synaptotagmins.Nat Cell Biol. 2016 May;18(5):504-15. doi: 10.1038/ncb3339. Epub 2016 Apr 11. Nat Cell Biol. 2016. PMID: 27065097 Free PMC article.
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