[Lymphopoiesis supported by osteolineage cells]

Abstract

Bone marrow(BM)and thymus are known as the primary lymphoid organs for B and T cells, respectively. However, the cell fate for T cell lineage commitment is already determined in the BM. Thus, the lymphopoiesis is critically controlled in the BM and, according to the recent advances in genetic mouse models, it appears that this process is strictly regulated by a series of osteolineage mesenchymal populations.