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Review
. 2016 Jul;11(7):964-75.
doi: 10.1016/j.jtho.2016.04.014. Epub 2016 Apr 23.

PD-L1 Expression in Lung Cancer

Hui Yu  1 , Theresa A Boyle  2 , Caicun Zhou  3 , David L Rimm  4 , Fred R Hirsch  5
Affiliations
Review

PD-L1 Expression in Lung Cancer

Hui Yu et al. J Thorac Oncol. 2016 Jul.

Erratum in

  • Erratum.
    [No authors listed] [No authors listed] J Thorac Oncol. 2017 Jan;12(1):157-159. doi: 10.1016/j.jtho.2016.11.001. J Thorac Oncol. 2017. PMID: 27988099 No abstract available.

Abstract

Immunotherapies targeted against programmed death ligand 1 (PD-L1) and its receptor (PD-1) have improved survival in a subset of patients with advanced lung cancer. PD-L1 protein expression has emerged as a biomarker that predicts which patients are more likely to respond to immunotherapy. The understanding of PD-L1 as a biomarker is complicated by the history of use of different immunohistochemistry platforms with different PD-L1 antibodies, scoring systems, and positivity cut-offs for immunotherapy clinical trials with different anti-PD-L1 and anti-PD-1 drugs. Herein, we summarize the brief history of PD-L1 as a biomarker and describe the challenges remaining to harmonize PD-L1 detection and interpretation for best patient care.

Keywords: Biomarker; Immunotherapy; Lung cancer; PD-L1.

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Conflict of interest statement

The remaining authors declare no conflict of interest.

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