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. 2016:2016:4579149.
doi: 10.1155/2016/4579149. Epub 2016 Mar 16.

Evaluation of Hepatoprotective Activity of Adansonia digitata Extract on Acetaminophen-Induced Hepatotoxicity in Rats

Abeer Hanafy  1 , Hibah M Aldawsari  2 , Jihan M Badr  3 , Amany K Ibrahim  4 , Seham El-Sayed Abdel-Hady  2
Affiliations

Evaluation of Hepatoprotective Activity of Adansonia digitata Extract on Acetaminophen-Induced Hepatotoxicity in Rats

Abeer Hanafy et al. Evid Based Complement Alternat Med. 2016.

Abstract

The methanol extract of the fruit pulp of Adansonia digitata L. (Malvaceae) was examined for its hepatoprotective activity against liver damage induced by acetaminophen in rats. The principle depends on the fact that administration of acetaminophen will be associated with development of oxidative stress. In addition, hepatospecific serum markers will be disturbed. Treatment of the rats with the methanol extract of the fruit pulp of Adansonia digitata L. prior to administration of acetaminophen significantly reduced the disturbance in liver function. Liver functions were measured by assessment of total protein, total bilirubin, ALP, ALT, and AST. Oxidative stress parameter and antioxidant markers were also evaluated. Moreover, histopathological evaluation was performed in order to assess liver case regarding inflammatory infiltration or necrosis. Animals were observed for any symptoms of toxicity after administration of extract of the fruit pulp of Adansonia digitata L. to ensure safety of the fruit extract.

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Figures

Figure 1
Figure 1
Effect of Adansonia digitata extract (200 mg/kg) and silymarin (100 mg/kg) on liver lipid peroxides (measured as MDA) concentration in acetaminophen-induced hepatotoxicity in rats. Each point represents the mean ± SD of ten rats.  ∗Significant difference compared with the control group (P < 0.05).  #Significant difference compared with the acetaminophen group (P < 0.05).
Figure 2
Figure 2
Effect of Adansonia digitata extract (200 mg/kg) and silymarin (100 mg/kg) on glutathione (GSH) level in acetaminophen-induced hepatotoxicity in rats. Each point represents the mean ± SD of ten rats.  ∗Significant difference compared with the control group (P < 0.05).  #Significant difference compared with the acetaminophen group (P < 0.05).
Figure 3
Figure 3
Effect of Adansonia digitata extract (200 mg/kg) and silymarin (100 mg/kg) on superoxide dismutase (SOD) activity in acetaminophen-induced hepatotoxicity in rats. Each point represents the mean ± SD of ten rats.  ∗Significant difference compared with the control group (P < 0.05).  #Significant difference compared with the acetaminophen group (P < 0.05).
Figure 4
Figure 4
Effect of Adansonia digitata extract (200 mg/kg) and silymarin (100 mg/kg) on liver catalase activity (CATA) measured in acetaminophen-induced hepatotoxicity in rats. Each point represents the mean ± SD of ten rats.  ∗Significant difference compared with the control group (P < 0.05).  #Significant difference compared with the acetaminophen group (P < 0.05).
Figure 5
Figure 5
Histopathological study of liver tissue in control, acetaminophen, silymarin, and Adansonia digitata extract groups of rats. (a) Control group showed normal liver architecture (H&E ×40). (b) Acetaminophen group showed marked hepatic cell necrosis and moderate inflammation and lymphocytic infiltrations (H&E ×40). (c) Acetaminophen + Silymarin (100 mg/kg) showed nearly normal liver structure (H&E ×100). (d) Acetaminophen + Adansonia digitata extract (200 mg/kg) showed mild necrosis and inflammation (H&E ×100).
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