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. 1989 Jan;26(1-2):128-31.
doi: 10.1007/BF02126584.

Glucocorticoid receptors in alveolar macrophages: methodological aspects of the determination of the number of glucocorticoid receptors per cell

P T van Hal  1 , E Mulder, H C Hoogsteden, C Hilvering, R Benner
Affiliations

Glucocorticoid receptors in alveolar macrophages: methodological aspects of the determination of the number of glucocorticoid receptors per cell

P T van Hal et al. Agents Actions. 1989 Jan.

Abstract

Among patients with asthma or chronic obstructive pulmonary diseases the response to glucocorticoids varies considerably. To investigate the possible relationship between clinical response and number of glucocorticoid receptors in alveolar macrophages or their KD value a micro receptor assay was developed. Assay conditions were adjusted because of receptor occupancy by endogenous or therapeutically used glucocorticoids and high aspecific binding.

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References

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