Soluble urokinase plasminogen activator receptor informs on the progression course after multiple injuries

Abstract

Purpose: The purpose of this study is to study the use of soluble urokinase plasminogen activator receptor (suPAR) for the prognosis of multiple organ dysfunction (MOF) after multiple traumas.

Methods: Serum suPAR was measured within the first 24 h after multiple injuries in 85 patients. Measurements were repeated after 4 d or at sepsis onset.

Results: Odds ratio for trauma-associated MOF was 4.09 (p: 0.026) with admission suPAR greater than 8 ng/ml. More than 40% increases of suPAR were associated with odds ratio 9.33 (p: 0.047) for severe sepsis.

Conclusions: suPAR is a useful surrogate biomarker for development of MOF and severe sepsis after multiple traumas.

Keywords: Multiple organ failure; severe sepsis; suPAR; trauma.