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. 2018 May;23(6):776-787.
doi: 10.1177/1359105316643375. Epub 2016 Apr 26.

A pilot study of a nurse-delivered cognitive behavioral therapy intervention (Ziphamandla) for adherence and depression in HIV in South Africa

Lena S Andersen  1 , Jessica F Magidson  2 , Conall O'Cleirigh  2   3 , Jessica E Remmert  2 , Ashraf Kagee  4 , Matthew Leaver  1 , Dan J Stein  1   5 , Steven A Safren  6 , John Joska  1
Affiliations

A pilot study of a nurse-delivered cognitive behavioral therapy intervention (Ziphamandla) for adherence and depression in HIV in South Africa

Lena S Andersen et al. J Health Psychol. 2018 May.

Abstract

Depression is prevalent among people living with HIV in South Africa and interferes with adherence to antiretroviral therapy. This study evaluated a nurse-delivered, cognitive behavioral therapy intervention for adherence and depression among antiretroviral therapy users with depression in South Africa ( n = 14). Primary outcomes were depression, antiretroviral therapy adherence, feasibility, and acceptability. Findings support robust improvements in mood through a 3-month follow up. Antiretroviral therapy adherence was maintained during the intervention period. Participant retention supports acceptability; however, modest provider fidelity despite intensive supervision warrants additional attention to feasibility. Future effectiveness research is needed to evaluate this nurse-delivered cognitive behavioral therapy intervention for adherence and depression in this context.

Keywords: HIV; South Africa; adherence; cognitive behavioral therapy; depression; low- and middle-income countries; task-sharing.

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Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Graphs of estimated means from the generalized mixed models. Note that error bars refer to standard errors.
See this image and copyright information in PMC

References

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