Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 Jul;27(7):1199-206.
doi: 10.1093/annonc/mdw181. Epub 2016 Apr 27.

Biomarkers associated with checkpoint inhibitors

G Manson  1 , J Norwood  1 , A Marabelle  2 , H Kohrt  3 , R Houot  4
Affiliations
Free article
Review

Biomarkers associated with checkpoint inhibitors

G Manson et al. Ann Oncol. 2016 Jul.
Free article

Abstract

Checkpoint inhibitors (CPI), namely anti-CTLA4 and anti-PD1/PD-L1 antibodies, demonstrated efficacy across multiple types of cancer. However, only subgroups of patients respond to these therapies. Additionally, CPI can induce severe immune-related adverse events (irAE). Biomarkers that predict efficacy and toxicity may help define the patients who may benefit the most from these costly and potentially toxic therapies. In this study, we review the main biomarkers that have been associated with the efficacy (pharmacodynamics and clinical benefit) and the toxicity (irAE) of CPIs in patients.

Keywords: biomarkers; cancer; checkpoint inhibitors; immunotherapy.

PubMed Disclaimer

Comment in

MeSH terms