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. 1989 Jan;33(1):30-4.
doi: 10.1128/AAC.33.1.30.

Zidovudine antagonizes the action of pyrimethamine in experimental infection with Toxoplasma gondii

D M Israelski  1 , C Tom, J S Remington
Affiliations

Zidovudine antagonizes the action of pyrimethamine in experimental infection with Toxoplasma gondii

D M Israelski et al. Antimicrob Agents Chemother. 1989 Jan.

Abstract

The effect of zidovudine (azidothymidine; AZT) on the action of pyrimethamine against Toxoplasma gondii was investigated. Zidovudine was found to antagonize the toxoplasmacidal effect of low concentrations of pyrimethamine in vitro, and in vitro synergism of pyrimethamine and sulfadiazine against T. gondii was reversed by zidovudine. Zidovudine also antagonized the therapeutic effect of pyrimethamine in mice acutely infected with T. gondii.

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References

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