Fibroblast Senescence as a Therapeutic Target of Myocardial Fibrosis: Beyond Spironolactone?

Affiliations

¹ Department of Cardiovascular Medicine, Humanitas Research Hospital and Humanitas University, Rozzano, Milan, Italy; Institute of Genetics and Biomedical Research National Research Council of Italy, Rozzano, Milan, Italy. Electronic address: gianluigi.condorelli@hunimed.eu.
² Department of Biomedical, Biotechnological and Translational Sciences, University of Parma, Parma, Italy.
³ Department of Cardiovascular Medicine, Humanitas Research Hospital and Humanitas University, Rozzano, Milan, Italy.

Free article

Editorial

Gianluigi Condorelli et al. J Am Coll Cardiol. 2016.

Free article

. 2016 May 3;67(17):2029-31.

doi: 10.1016/j.jacc.2016.02.048.

¹ Department of Cardiovascular Medicine, Humanitas Research Hospital and Humanitas University, Rozzano, Milan, Italy; Institute of Genetics and Biomedical Research National Research Council of Italy, Rozzano, Milan, Italy. Electronic address: gianluigi.condorelli@hunimed.eu.
² Department of Biomedical, Biotechnological and Translational Sciences, University of Parma, Parma, Italy.
³ Department of Cardiovascular Medicine, Humanitas Research Hospital and Humanitas University, Rozzano, Milan, Italy.

No abstract available

Keywords: aging; fibroblast; gene expression; heart failure; tumor suppressor genes.

Comment on

Essential Role for Premature Senescence of Myofibroblasts in Myocardial Fibrosis.
Meyer K, Hodwin B, Ramanujam D, Engelhardt S, Sarikas A. Meyer K, et al. J Am Coll Cardiol. 2016 May 3;67(17):2018-28. doi: 10.1016/j.jacc.2016.02.047. J Am Coll Cardiol. 2016. PMID: 27126529