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Review
. 2016 Jan-Mar;8(1):1-4.
doi: 10.4103/0974-7753.179393.

Bird's Nest View from a Dermatologist's Eye

Sethi Anisha  1 , Kaur Sukhjot  1 , Gupta Kumar Sunil  1 , Puri Sandeep  2
Affiliations
Review

Bird's Nest View from a Dermatologist's Eye

Sethi Anisha et al. Int J Trichology. 2016 Jan-Mar.

Abstract

Plica neuropathica also known as "birds nest" is irreversible matting of hair seen in otherwise healthy individuals and is usually associated with use of ionic/herbal soaps, shampoos, parasitic infestations, psychiatric alterations, or neglect. Anagen effluvium is a known side effect of many immunosuppressive drugs. Rarely matting of hair has been reported following azathioprine. We report plica neuropathica in two chronically ill patients on immunosuppressive drugs, that is, azathioprine and methotrexate along with a review of literature of its etiological factors and pathogenesis.

Keywords: Azathioprine; matting of hair; methotrexate; plica neuropathica.

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Figures

Figure 1
Figure 1
The matting of hair in Case 1. Also diffuse hair loss form the scalp can be appreciated
Figure 2
Figure 2
(a) Methotrexate induced erythema multiforme lesions in Case 2. (b) Matting of hair in the same patient
Figure 3
Figure 3
Plausible mechanisms of pathogenesis of plica neuropathica
See this image and copyright information in PMC

References

    1. Le Page JF. On neuropathic plica. Br Med J. 1884;1:160. - PMC - PubMed
    1. Kumar PN, Antony B, Chakravarthy A, Koyamu AM. Plica neuropathica (polonica) in schizophrenia – A case report and review of literature. Indian J Psychol. 2001;43:281–3. - PMC - PubMed
    1. Kwinter J, Weinstein M. Plica neuropathica: Novel presentation of a rare disease. Clin Exp Dermatol. 2006;31:790–2. - PubMed
    1. Joshi R, Singh S. Plica neuropathica (Plica polonica) following azathioprine-induced pancytopenia. Int J Trichology. 2010;2:110–2. - PMC - PubMed
    1. Ramanan C, Ghorpade A. Plica neuropathica after using herbal soap. Int J Dermatol. 1993;32:200–1. - PubMed