Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016:2016:3067123.
doi: 10.1155/2016/3067123. Epub 2016 Mar 22.

Comparison of Imaging Characteristics of (124)I PET for Determination of Optimal Energy Window on the Siemens Inveon PET

A Ram Yu  1 , Hee-Joung Kim  2 , Sang Moo Lim  3 , Jin Su Kim  4
Affiliations

Comparison of Imaging Characteristics of (124)I PET for Determination of Optimal Energy Window on the Siemens Inveon PET

A Ram Yu et al. Biomed Res Int. 2016.

Abstract

Purpose. (124)I has a half-life of 4.2 days, which makes it suitable for imaging over several days over its uptake and washout phases. However, it has a low positron branching ratio (23%), because of prompt gamma coincidence due to high-energy γ-photons (602 to 1,691 keV), which are emitted in cascade with positrons. Methods. In this study, we investigated the optimal PET energy window for (124)I PET based on image characteristics of reconstructed PET. Image characteristics such as nonuniformities, recovery coefficients (RCs), and the spillover ratios (SORs) of (124)I were measured as described in NEMA NU 4-2008 standards. Results. The maximum and minimum prompt gamma coincidence fraction (PGF) were 33% and 2% in 350~800 and 400~590 keV, respectively. The difference between best and worst uniformity in the various energy windows was less than 1%. The lowest SORs of (124)I were obtained at 350~750 keV in nonradioactive water compartment. Conclusion. Optimal energy window should be determined based on image characteristics. Our developed correction method would be useful for the correction of high-energy prompt gamma photon in (124)I PET. In terms of the image quality of (124)I PET, our findings indicate that an energy window of 350~750 keV would be optimal.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Nonuniformity (%SD) in the uniform region of the NEMA NU 4 image quality phantom.
Figure 2
Figure 2
NECR curve for different energy windows (a) at the lower threshold was 350 keV in all cases except 400~590 keV. Normalized NECR variation according to ULD (b).
See this image and copyright information in PMC

References

    1. Bruehlmeier M., Roelcke U., Schubiger P. A., Ametamey S. M. Assessment of hypoxia and perfusion in human brain tumors using PET with 18F-fluoromisonidazole and 15O-H2O. Journal of Nuclear Medicine. 2004;45(11):1851–1859. - PubMed
    1. Castellani M., Colombo A., Giordano R., et al. The role of PET with 13N-ammonia and 18F-FDG in the assessment of myocardial perfusion and metabolism in patients with recent AMI and intracoronary stem cell injection. Journal of Nuclear Medicine. 2010;51(12):1908–1916. doi: 10.2967/jnumed.110.078469. - DOI - PubMed
    1. Jentzen W., Weise R., Kupferschläger J., et al. Iodine-124 PET dosimetry in differentiated thyroid cancer: recovery coefficient in 2D and 3D modes for PET(/CT) systems. European Journal of Nuclear Medicine and Molecular Imaging. 2008;35(3):611–623. doi: 10.1007/s00259-007-0554-7. - DOI - PubMed
    1. Jentzen W., Hobbs R. F., Stahl A., Knust J., Sgouros G., Bockisch A. Pre-therapeutic 124I PET(/CT) dosimetry confirms low average absorbed doses per administered 131I activity to the salivary glands in radioiodine therapy of differentiated thyroid cancer. European Journal of Nuclear Medicine and Molecular Imaging. 2010;37(5):884–895. doi: 10.1007/s00259-009-1351-2. - DOI - PMC - PubMed
    1. Lee D. S., Paeng J. C. Molecular nuclear cardiac imaging. Korean Journal of Nuclear Medicine. 2004;38(2):175–179.

MeSH terms