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Comment
. 2016 Aug 1;22(15):3710-2.
doi: 10.1158/1078-0432.CCR-16-0582. Epub 2016 Apr 29.

Heads Up! Predictive Gene Signatures in Head and Neck Cancer May Be Coming Soon

Nicole G Chau  1 , Peter S Hammerman  2
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Heads Up! Predictive Gene Signatures in Head and Neck Cancer May Be Coming Soon

Nicole G Chau et al. Clin Cancer Res. .

Abstract

Cetuximab-platinum chemotherapy is used for recurrent/metastatic head and neck squamous cell carcinoma (HNSCC); however, a minority of patients benefit. Gene expression profiling (GEP) of HNSCCs with prolonged responses to cetuximab-chemotherapy demonstrate basal subtype traits including signatures of EGFR signaling and hypoxic differentiation. GEP of short-response patients show RAS activation. Clin Cancer Res; 22(15); 3710-2. ©2016 AACRSee related article by Bossi et al., p. 3961.

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