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Review
. 2016 Apr 29;14(1):29.
doi: 10.1186/s12969-016-0090-8.

Pediatric complex regional pain syndrome: a review

Rotem Weissmann  1   2 , Yosef Uziel  3   4
Affiliations
Review

Pediatric complex regional pain syndrome: a review

Rotem Weissmann et al. Pediatr Rheumatol Online J. .

Abstract

Complex regional pain syndrome (CRPS) is a chronic, intensified localized pain condition that can affect children and adolescents as well as adults, but is more common among adolescent girls. Symptoms include limb pain; allodynia; hyperalgesia; swelling and/or changes in skin color of the affected limb; dry, mottled skin; hyperhidrosis and trophic changes of the nails and hair. The exact mechanism of CRPS is unknown, although several different mechanisms have been suggested. The diagnosis is clinical, with the aid of the adult criteria for CRPS. Standard care consists of a multidisciplinary approach with the implementation of intensive physical therapy in conjunction with psychological counseling. Pharmacological treatments may aid in reducing pain in order to allow the patient to participate fully in intensive physiotherapy. The prognosis in pediatric CRPS is favorable.

Keywords: CRPS; Chronic pain; Complex regional pain syndrome; Pain amplification syndrome; Pediatric.

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References

    1. Matles AI. Reflex sympathetic dystrophy in a child. A case report. Bull Hosp Joint Dis. 1971;32(2):193–7. - PubMed
    1. Merskey H, Bogduk N. Classification of chronic pain : descriptions of chronic pain syndromes and definitions of pain terms. 2. Seattle: IASP Press; 1994.
    1. Low AK, Ward K, Wines AP. Pediatric complex regional pain syndrome. J Pediatr Orthop. 2007;27(5):567–72. doi: 10.1097/BPO.0b013e318070cc4d. - DOI - PubMed
    1. Ho ES, Ponnuthurai J, Clarke HM. The incidence of idiopathic musculoskeletal pain in children with upper extremity injuries. J Hand Ther. 2014;27(1):38–43. doi: 10.1016/j.jht.2013.10.002. - DOI - PubMed
    1. Wilder RT, Berde CB, Wolohan M, Vieyra MA, Masek BJ, Micheli LJ. Reflex sympathetic dystrophy in children. Clinical characteristics and follow-up of seventy patients. J Bone Joint Surg Am. 1992;74(6):910–9. - PubMed