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Review
. 2016 Aug;14(4):181-90.
doi: 10.1016/j.gpb.2016.03.003. Epub 2016 Apr 27.

A Biobank for Long-term and Sustainable Research in the Field of Congenital Heart Disease in Germany

Thomas Pickardt  1 , Eva Niggemeyer  2 , Ulrike M M Bauer  3 , Hashim Abdul-Khaliq  4 ; Competence Network for Congenital Heart Defects Investigators
Affiliations
Review

A Biobank for Long-term and Sustainable Research in the Field of Congenital Heart Disease in Germany

Thomas Pickardt et al. Genomics Proteomics Bioinformatics. 2016 Aug.

Abstract

Congenital heart disease (CHD) is the most frequent birth defect (0.8%-1% of all live births). Due to the advance in prenatal and postnatal early diagnosis and treatment, more than 90% of these patients survive into adulthood today. However, several mid- and long-term morbidities are dominating the follow-up of these patients. Due to the rarity and heterogeneity of the phenotypes of CHD, multicenter registry-based studies are required. The CHD-Biobank was established in 2009 with the aim to collect DNA from patients and their parents (trios) or from affected families, as well as cardiovascular tissues from patients undergoing corrective heart surgery for cardiovascular malformations. Clinical/phenotype data are matched to the International Paediatric and Congenital Cardiac Code (IPCCC) and the International Statistical Classification of Diseases and Related Health Problems 10th Revision (ICD-10). The DNA collection currently comprises samples from approximately 4200 participants with a wide range of CHD phenotypes. The collection covers about 430 trios and 120 families with more than one affected member. The cardiac tissue collection comprises 1143 tissue samples from 556 patients after open heart surgery. The CHD-Biobank provides a comprehensive basis for research in the field of CHD with high standards of data privacy, IT management, and sample logistics.

Keywords: Biorepository; Congenital heart defects; DNA; Genetic research; Multi-center research.

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Figures

Figure 1
Figure 1
Structure of CNCHD and NRCHD
Figure 2
Figure 2
Tissue-sample collection kit The complete list of heart tissue types can be found in Figure 5.
Figure 3
Figure 3
Age distribution of the affected donors The age here refers to the documented age when samples were taken.
Figure 4
Figure 4
Distribution of the affected donors born with additional syndromes/disorders
Figure 5
Figure 5
Type and number of tissue samples from heart surgery
See this image and copyright information in PMC

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