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. 2016 Aug 1;214(3):475-8.
doi: 10.1093/infdis/jiw170. Epub 2016 Apr 30.

Association Analysis Suggests SOD2 as a Newly Identified Candidate Gene Associated With Leprosy Susceptibility

Geovana Brotto Ramos  1 , Heloisa Salomão  1 , Angela Schneider Francio  1 , Vinícius Medeiros Fava  2 , Renata Iani Werneck  3 , Marcelo Távora Mira  3
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Association Analysis Suggests SOD2 as a Newly Identified Candidate Gene Associated With Leprosy Susceptibility

Geovana Brotto Ramos et al. J Infect Dis. .

Abstract

Genetic studies have identified several genes and genomic regions contributing to the control of host susceptibility to leprosy. Here, we test variants of the positional and functional candidate gene SOD2 for association with leprosy in 2 independent population samples. Family-based analysis revealed an association between leprosy and allele G of marker rs295340 (P = .042) and borderline evidence of an association between leprosy and alleles C and A of markers rs4880 (P = .077) and rs5746136 (P = .071), respectively. Findings were validated in an independent case-control sample for markers rs295340 (P = .049) and rs4880 (P = .038). These results suggest SOD2 as a newly identified gene conferring susceptibility to leprosy.

Keywords: SOD2; association study; infectious diseases; leprosy; polymorphism.

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