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. 1989 Apr;59(4):622-6.
doi: 10.1038/bjc.1989.126.

Genetic and immunopathological findings in a lymphoma family

H T Lynch  1 , J N Marcus, D D Weisenburger, P Watson, M L Fitzsimmons, H Grierson, D M Smith, J Lynch, D Purtilo
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Free PMC article

Genetic and immunopathological findings in a lymphoma family

H T Lynch et al. Br J Cancer. 1989 Apr.
Free PMC article

Abstract

We have studied a remarkable family with seven cases of malignant lymphoma extending through three generations wherein five sisters and their mother had histopathologically documented non-Hodgkin's lymphoma, while a granddaughter had Hodgkin's disease. An immunological study of three lymphoma survivors, nine of their first degree relatives, and four spouse controls was undertaken. Significant findings consisted of a depressed serum IgG3 level in four of the nine first-degree relatives; in two of these four, lymphocyte stimulation by both pokeweed mitogen and concanavalin A were significantly depressed. The subtle immunological abnormalities present in this kindred may be associated with the pathogenesis of the lymphomas.

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