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. 1989 Jan 24;28(2):593-9.
doi: 10.1021/bi00428a027.

1H NMR assignment and secondary structural elements of human transforming growth factor alpha

S C Brown  1 , L Mueller, P W Jeffs
Affiliations

1H NMR assignment and secondary structural elements of human transforming growth factor alpha

S C Brown et al. Biochemistry. .

Abstract

The 1H NMR spectrum of human transforming growth factor alpha (hTGF-alpha) has been completely assigned, and secondary structural elements have been identified as a preliminary step in determining the structure of this protein by distance geometry methods. Many of these structural elements closely correspond to those previously found in a truncated human EGF [Cooke et al. (1987) Nature (London) 327, 339-341] and murine EGF [Montelione et al. (1987) Proc. Natl. Acad. Sci. U.S.A. 84, 5226-5230]. These include the presence of an antiparallel beta-sheet between residues G19 and C34 with a type I beta-turn at V25-D28, a type II beta-turn at H35-Y38, and another short beta-sheet between residues Y38-V39 and H45-A46.

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