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. 2016 Jun;32(4):381-9.
doi: 10.3109/02656736.2016.1157903. Epub 2016 May 1.

A systematic review of regional hyperthermia therapy in bladder cancer

Thomas A Longo  1 , Ajay Gopalakrishna  1 , Matvey Tsivian  1 , Megan Van Noord  2 , Coen R Rasch  3 , Brant A Inman  1 , Elisabeth D Geijsen  3
Affiliations

A systematic review of regional hyperthermia therapy in bladder cancer

Thomas A Longo et al. Int J Hyperthermia. 2016 Jun.

Abstract

Context: Bladder cancer therapy remains suboptimal as morbidity and mortality remain high amongst those with non-muscle-invasive and muscle-invasive disease. Regional hyperthermia therapy (RHT) is a promising adjunctive therapy being tested in multiple clinical contexts.

Objective: The aim of this study was to systematically review the literature on the efficacy and toxicity of RHT.

Evidence acquisition: This systematic review was registered with the PROSPERO database (Registration number: CRD42015025780) and was conducted according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. We queried PubMed, EMBASE, and Cochrane libraries. Two reviewers reviewed abstracts independently and a third reviewer arbitrated disagreements. The last search was performed on 28 August 2015. A descriptive analysis was performed and quality assessment was conducted using the Newcastle-Ottawa Quality Assessment Scale for observational studies, and the Cochrane Risk of Bias Assessment Tool for trials.

Evidence synthesis: We identified 859 publications in the initial search, of which 24 met inclusion criteria for full-text review. Of these, we were able to obtain data on the outcomes of interest for 15 publications.

Conclusions: The review underscores the limited nature of the evidence; definitive conclusions are elusive. However, the promising results of RHT in the setting of intravesical chemotherapy, chemotherapy and radiotherapy show a trend towards legitimate efficacy.

Keywords: Bladder cancer; chemohyperthermia; radiohyperthermia; regional hyperthermia therapy; urothelial carcinoma.

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Conflict of interest statement

Declaration of interests

The authors report no declarations of interest.

Figures

Figure 1
Figure 1
Flow diagram of evidence acquisition
See this image and copyright information in PMC

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