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. 2016 May;31(5):715-23.
doi: 10.3346/jkms.2016.31.5.715. Epub 2016 Mar 29.

Serotype Distribution and Antimicrobial Susceptibilities of Invasive Streptococcus pneumoniae Isolates from Adults in Korea from 1997 to 2012

Chung Jong Kim  1 , Jin-Su Song  1 , Su-Jin Choi  1 , Kyoung Ho Song  1 , Pyeong Gyun Choe  1 , Wan Beom Park  1 , Ji Hwan Bang  1 , Eu Suk Kim  1 , Sang Won Park  1 , Hong Bin Kim  1 , Nam-Joong Kim  1 , Eui-Chong Kim  2 , Myoung-don Oh  1
Affiliations

Serotype Distribution and Antimicrobial Susceptibilities of Invasive Streptococcus pneumoniae Isolates from Adults in Korea from 1997 to 2012

Chung Jong Kim et al. J Korean Med Sci. 2016 May.

Abstract

In Republic of Korea, a 7-valent pneumococcal conjugated vaccine (PCV7) was licensed for use in infants in 2003, and 13-valent PCV (PCV13) replaced it since 2010. We investigated trends in serotype distribution and antibiotic susceptibility of pneumococcal isolates from adult patients with invasive pneumococcal diseases (IPD). Invasive pneumococcal isolates from adult patients of ≥ 16 years of age were collected from 1997 to 2012. Serotypes of the isolates were determined by the Quellung reaction. Distribution of serotypes was analyzed according to the vaccine types. Antibiotic susceptibility was tested by using E-test strips. A total of 272 invasive pneumococcal isolates were included. The most common serotypes were serotype 19F (8.5%, 23/272), and serotype 3 (8.1%, 22/272), and 24.6% (67/272) of the isolates were of non-vaccine serotypes. Of the 272 isolates, 2.6% (7/272) were penicillin MICs of ≥ 4 µg/mL. The proportion of the PCV13 serotypes decreased from 63.3% (50/79) in 1997-2003 to 48.6% (17/35) in 2011-2012, whereas that of non-vaccine serotypes was 26.6% (21/79) and 25.7% (9/35), respectively, for the same periods. The proportion of the PCV13 serotypes showed a decreasing trend among adult patients with IPD over the study period.

Keywords: Microbial Sensitivity Tests; Pneumococcal Vaccines; Serotypes; Streptococcus pneumoniae.

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Conflict of interest statement

DISCLOSURE: The authors have no potential conflicts of interest to disclose.

References

    1. Kwong JC, Crowcroft NS, Campitelli MA, Ratnasingham S, Daneman N, Deeks SL, Manuel DG. Ontario Burden of Infectious Disease Study. Toronto: Institute for Clinical Evaluative Sciences; Ontario Agency for Health Protection and Promotion; 2010.
    1. All Party Parliamentary Group for Child Health and Vaccine Preventable Diseases (GB) Improving Global Health by Preventing Pneumococcal Disease. London: All Party Parliamentary Group for Child Health and Vaccine Preventable Diseases; 2008. pp. 1–35.
    1. Weinberger DM, Trzciński K, Lu YJ, Bogaert D, Brandes A, Galagan J, Anderson PW, Malley R, Lipsitch M. Pneumococcal capsular polysaccharide structure predicts serotype prevalence. PLoS Pathog. 2009;5:e1000476. - PMC - PubMed
    1. Brueggemann AB, Griffiths DT, Meats E, Peto T, Crook DW, Spratt BG. Clonal relationships between invasive and carriage Streptococcus pneumoniae and serotype- and clone-specific differences in invasive disease potential. J Infect Dis. 2003;187:1424–1432. - PubMed
    1. Henrichsen J. Six newly recognized types of Streptococcus pneumoniae. J Clin Microbiol. 1995;33:2759–2762. - PMC - PubMed

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