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. 2016 May;31(5):724-8.
doi: 10.3346/jkms.2016.31.5.724. Epub 2016 Mar 28.

Translation and Validation of a Korean Version of the Xerostomia Inventory in Patients with Primary Sjögren's Syndrome

Jennifer Lee  1 , Jung Hee Koh  1 , Seung-Ki Kwok  1 , Sung-Hwan Park  1
Affiliations

Translation and Validation of a Korean Version of the Xerostomia Inventory in Patients with Primary Sjögren's Syndrome

Jennifer Lee et al. J Korean Med Sci. 2016 May.

Abstract

This study was conducted to generate and validate a cross-culturally adapted Korean version of the xerostomia inventory (XI), an 11-item questionnaire designed to measure the severity of xerostomia. The original English version of the XI was translated into Korean according to the guidelines for cross-cultural adaptation of health-related quality-of-life measures. Among a prospective cohort of primary Sjögren's syndrome (pSS) in Korea, 194 patients were analyzed. Internal consistency was evaluated by using Cronbach's alpha, and test-retest reliability was obtained by using an intraclass correlation coefficient (ICC) analysis. Construct validity was investigated by performing a correlation analysis between XI total score and salivary flow rate (SFR). Cronbach's alpha for internal consistency was 0.868, and the ICC for test-retest reliability ranged from 0.48 to 0.827, with a median value of 0.72. Moderate negative correlations between XI score and stimulated SFR, unstimulated SFR, and differential (stimulated minus unstimulated) SFR were observed (Spearman's rho, ρ = -0.515, -0.447, and -0.482, respectively; P < 0.001). The correlation analysis between the visual analogue scale (VAS) score of overall dryness and SFR indicated a smaller ρ value (-0.235 [P = 0.006], -0.243 [P = 0.002], and -0.252 [P = 0.003], respectively), which supports that XI more accurately reflects the degree of xerostomia in the pSS patients. In conclusion, the Korean version of the XI is a reliable tool to estimate the severity of xerostomia in patients with pSS.

Keywords: Sjögren’s Syndrome, Cross-Cultural Adaptation; Xerostomia Inventory.

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Conflict of interest statement

DISCLOSURE: The authors have no potential conflicts of interest to disclose.

Figures

Fig. 1
Fig. 1
Spearman’s correlation between the Xerostomia inventory (XI) total scores and salivary flow rate (SFR)s. The correlations between XI total scores and the resting (A), stimulated (B), and differential (stimulated minus resting) (C) SFRs were analyzed. The dotted lines depict 95% confidence intervals.
See this image and copyright information in PMC

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