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Case Reports
. 2016 Mar;10(3):FD01-2.
doi: 10.7860/JCDR/2016/17768.7404. Epub 2016 Mar 1.

Metolazone Associated Stevens Johnson Syndrome-Toxic Epidermal Necrolysis Overlap

Prabhat Kumar  1 , Ajay Chauhan  2 , Riyaz Charaniya  3 , Anindya Ghosh  3 , Vaibhav Tandon  3
Affiliations
Case Reports

Metolazone Associated Stevens Johnson Syndrome-Toxic Epidermal Necrolysis Overlap

Prabhat Kumar et al. J Clin Diagn Res. 2016 Mar.

Abstract

Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are severe mucocutaneous disease with high mortality rate. It is characterised by severe necrosis and detachment of the epidermis. Drugs are the most common triggering agent for SJS/TEN. These are commonly reported with the use of aromatic antiepileptics, antiretrovirals, allopurinol, NSAID'S and sulfonamide antibiotics. Non antibiotic sulfonamides rarely cause SJS/TEN. Metolazone is a well known diuretic and is extensively used by clinicians. Although this drug is in market for last several decades, no case of SJS/TEN has been reported till date. We report a rare case of metolazone induced SJS/TEN overlap in a 55-year-old lady.

Keywords: Naranjo Probability Scale; SCORTEN score; Thiazide diuretic.

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Figures

[Table/Fig-1]:
[Table/Fig-1]:
Maculo-papular rash present over lower abdomen with few blister formation.
[Table/Fig-2]:
[Table/Fig-2]:
Extensive skin excoriation with ulceration over lower back.
See this image and copyright information in PMC

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