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Case Reports
. 2016 Mar;10(3):OD08-9.
doi: 10.7860/JCDR/2016/16872.7361. Epub 2016 Mar 1.

Antisynthetase Syndrome: A Rare Cause for ILD

Hj Gayathri Devi  1 , Md Majeed Pasha  2 , Mantha Sathya Padmaja  2 , Sujith Halappa  2
Affiliations
Case Reports

Antisynthetase Syndrome: A Rare Cause for ILD

Hj Gayathri Devi et al. J Clin Diagn Res. 2016 Mar.

Abstract

Anti-Synthetase Syndrome (ASS) is a rare autoimmune disorder characterized by Interstitial Lung Disease (ILD), inflammatory myositis, fever, Raynaud's phenomenon, mechanic's hand, and inflammatory polyarthritis in the setting of antibodies against amino acyl-transfer RNA synthetases, with anti-Jo-1 antibody being the most common. It can sometimes present as interstitial lung disease without any other expression of the syndrome. Clinical and radiological features can be similar to atypical pneumonia and could be a challenge to diagnose at an early stage. Prognosis is generally poor, especially when there is associated ILD and delay in diagnosis can lead to increase in morbidity due to progression of pulmonary involvement. We report a patient of ASS presenting with ILD, diagnosed early and treated successfully with immunosupression.

Keywords: Anti-jo-1; Cryptogenic; Organizing; Pneumonia.

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Figures

[Table/Fig-1]:
[Table/Fig-1]:
Chest X-ray showing bilateral non-homogeneous opacities.
[Table/Fig-2a, b]:
[Table/Fig-2a, b]:
CT Thorax showing bilateral alveolar opacities mainly in the basal region with air bronchogram.
[Table/Fig-3]:
[Table/Fig-3]:
Chest X-ray showing good clearance of the opacities.
See this image and copyright information in PMC

References

    1. Solomon J, Swigris JJ, Brown KK. Myositis-related interstitial lung disease and antisynthetase syndrome. Jornalbrasileiro de pneumologia :publicacaooficial da SociedadeBrasileira de Pneumologia e Tisilogia. 2011;37(1):100–09. - PMC - PubMed
    1. Marguerie C, Bunn CC, Beynon HL, Bernstein RM, Hughes JM, So AK, et al. Polymyositis, pulmonary fibrosis and autoantibodies to aminoacyl-tRNAsynthetase enzymes. Q J Med. 1990;77:1019–38. - PubMed
    1. Jan Tore Gran and ØyvindMolberg (2011). The Antisynthetase Syndrome, Idiopathic Inflammatory Myopathies - Recent Developments, Prof. Jan Tore Gran (Ed.), ISBN: 978-953-307-694-2, InTech, Available from: http://www.intechopen.com/books/idiopathic-inflammatory-myopathies-recen....
    1. Vancsa A, Csipo I, Nemeth J, Devenyi K, Gergely L, Danko K. Characteristics of interstitial lung disease in SS-A positive/Jo-1 positive inflammatory myopathy patients. Rheumatol Int. 2009;29(9):989–94. - PubMed
    1. Katzap E, Barilla-LaBarca ML, Marder G. Antisynthetase syndrome. CurrRheumatol Rep. 2011;13:175–181. - PubMed

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