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Review
. 2016 Jul;14(4):277-286.
doi: 10.2450/2016.0168-15. Epub 2016 Feb 17.

Is solvent/detergent plasma better than standard fresh-frozen plasma? A systematic review and an expert consensus document

Marco Marietta  1 , Massimo Franchini  2 , M Lucia Bindi  3 , Francesco Picardi  4 , Matteo Ruggeri  5 , Giustina De Silvestro  6
Affiliations
Review

Is solvent/detergent plasma better than standard fresh-frozen plasma? A systematic review and an expert consensus document

Marco Marietta et al. Blood Transfus. 2016 Jul.

Abstract

Background: Only a few studies have compared solvent/detergent plasma (SD-plasma) to standard fresh-frozen plasma (FFP) in terms of efficacy and safety.

Materials and methods: A systematic review was performed in order to develop a consensus document on the use of SD-plasma. Moreover, a pharmacoeconomic study was performed in order to assess whether the use of SD-plasma can be cost-effective with respect to the use of FFP. A multidisciplinary panel used the systematic review and the GRADE methodology to develop evidence-based recommendations on this topic.

Results: Based on moderate to very low quality evidence, the panel developed the following consensus statements: (i) the panel suggested that SD-plasma is safer than FFP; (ii) the panel could not express for or against a greater efficacy of SD-plasma as compared to FFP; (iii) the panel suggested that in patients undergoing liver transplantation SD-plasma can be preferred over FFP; (iv) the panel suggested that SD-plasma can be preferred over FFP in patients with thrombotic thrombocytopenic purpura undergoing plasma-exchange procedures; (v) the panel could not recommend for or against preferring SD-plasma over FFP in critical care patients; and (vi) the panel suggested that the use of SD-plasma can be cost-effective with respect to the use of FFP.

Discussion: Data from additional randomised studies are needed to establish more definitive guidelines on the use of SD-plasma.

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