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. 1989 Feb 20;480(1-2):105-10.
doi: 10.1016/0006-8993(89)91572-2.

Cholecystokinin-octapeptide antagonizes morphine analgesia in periaqueductal gray of the rat

Y Li  1 , J S Han
Affiliations

Cholecystokinin-octapeptide antagonizes morphine analgesia in periaqueductal gray of the rat

Y Li et al. Brain Res. .

Abstract

The analgesic effect of systemic morphine (5 mg/kg, s.c.) was dose-dependently antagonized by CCK-8 administered to the periaqueductal gray (PAG) of the rat. This effect could be reversed by proglumide, a CCK-receptor antagonist. The effect of morphine analgesia was potentiated by proglumide administered to PAG. These results are compatible with the notion that PAG is a strategic site where CCK-8 exerts an antiopioid activity.

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