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Review
. 2016 Apr 28;17(5):643.
doi: 10.3390/ijms17050643.

The Role of Chemokines in Promoting Colorectal Cancer Invasion/Metastasis

Yoshiro Itatani  1   2 , Kenji Kawada  3 , Susumu Inamoto  4 , Takamasa Yamamoto  5 , Ryotaro Ogawa  6 , Makoto Mark Taketo  7   8 , Yoshiharu Sakai  9
Affiliations
Review

The Role of Chemokines in Promoting Colorectal Cancer Invasion/Metastasis

Yoshiro Itatani et al. Int J Mol Sci. .

Abstract

Colorectal cancer (CRC) is one of the leading causes of cancer-related death worldwide. Although most of the primary CRC can be removed by surgical resection, advanced tumors sometimes show recurrences in distant organs such as the liver, lung, lymph node, bone or peritoneum even after complete resection of the primary tumors. In these advanced and metastatic CRC, it is the tumor-stroma interaction in the tumor microenvironment that often promotes cancer invasion and/or metastasis through chemokine signaling. The tumor microenvironment contains numerous host cells that may suppress or promote cancer aggressiveness. Several types of host-derived myeloid cells reside in the tumor microenvironment, and the recruitment of them is under the control of chemokine signaling. In this review, we focus on the functions of chemokine signaling that may affect tumor immunity by recruiting several types of bone marrow-derived cells (BMDC) to the tumor microenvironment of CRC.

Keywords: cancer immunity; colon cancer; myeloid cells; tumor microenvironment.

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Figures

Figure 1
Figure 1
Chemokine signaling that mediates interactions between CRC cells and myeloid cells in the tumor microenvironment.
See this image and copyright information in PMC

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