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. 2016 Mar;22(2):149-58.
doi: 10.1097/PRA.0000000000000142.

Adjunctive Behavioral Activation for the Treatment of Bipolar Depression: A Proof of Concept Trial

Lauren M Weinstock  1 , Caitlin Melvin, Mary K Munroe, Ivan W Miller
Affiliations

Adjunctive Behavioral Activation for the Treatment of Bipolar Depression: A Proof of Concept Trial

Lauren M Weinstock et al. J Psychiatr Pract. 2016 Mar.

Abstract

Background: Grounded in a model focused on exposure to response-contingent positive reinforcement, and with evidence supporting its acute treatment effects for unipolar depression, an adjunctive behavioral activation (BA) intervention may be especially well suited to the treatment of bipolar depression. The goal of this study was to modify BA for the adjunctive treatment of bipolar depression and to pilot it in a proof of concept trial to assess its preliminary feasibility and acceptability for this population.

Methods: Twelve adults with bipolar depression were recruited from hospital settings and enrolled in a 20-week open trial of the modified BA, delivered in 16 outpatient sessions, as an adjunct to community pharmacotherapy for bipolar disorder. Symptom severity was assessed at pretreatment and posttreatment by an independent evaluator. Patient satisfaction was also assessed posttreatment.

Results: Feasibility and acceptability were high, with 10 of 12 patients completing treatment, an average of 14.8 (SD=5.2) of 16 sessions attended, and high levels of self-reported treatment satisfaction. Patients exhibited statistically significant improvement from pretreatment to posttreatment on measures of depressive symptoms, manic symptoms, and severity of suicidal ideation.

Conclusions: Although preliminary and requiring replication in a larger sample, these study data suggest that a modified BA intervention may offer promise as an adjunctive approach for the acute treatment of bipolar depression. Future studies that use more rigorous randomized controlled designs and that directly assess potential mechanisms of action are recommended.

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Conflict of interest statement

Conflicts of Interest

The authors declare no conflicts of interest.

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