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Comment
. 2016 May 9;213(3):297-9.
doi: 10.1083/jcb.201604084. Epub 2016 May 2.

Lipoprotein secretion: It takes two to TANGO

Suzanne R Pfeffer  1
Affiliations
Comment

Lipoprotein secretion: It takes two to TANGO

Suzanne R Pfeffer. J Cell Biol. .

Abstract

An unsolved mystery in cell biology is how unusually large secretory cargoes are exported from the endoplasmic reticulum. In this issue, Santos et al. (2016. J. Cell Biol http://dx.doi.org/10.1083/jcb.201603072) report the function of a Mia2/cTAGE5 transcript fusion, named TALI, in the endoplasmic reticulum export of chylomicrons and very low-density lipoproteins, but not collagen XII.

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Figures

Figure 1.
Figure 1.
TALI, TANGO1, and related human transcripts. Transcript map derived from human chromosome 14 (39,233,916–39,253,655; top row) and chromosome 1 (222,618,086–222,668,012; bottom row) using Gencode version 22 comprehensive transcript set, redrawn from the University of California Santa Cruz Genome Browser on human (Dec. 2013 [GRCh38/hg38] assembly). Exons are shown as bars. Regions of these genes that reside in the ER lumen or on the ER cytoplasmic surface are indicated.
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