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Review
. 2016 Jul;21(4):365-72.
doi: 10.1007/s10741-016-9554-7.

Thyroid hormones and cardiac remodeling

Dennis V Cokkinos  1   2 , Stavros Chryssanthopoulos  3
Affiliations
Review

Thyroid hormones and cardiac remodeling

Dennis V Cokkinos et al. Heart Fail Rev. 2016 Jul.

Abstract

Thyroid hormones have many cardioprotective actions expressed mainly through the action of T3 on thyroid receptors α1 and β1. They are procontractile anti-apoptotic, anti-inflammatory, and anti-fibrotic, promote angiogenesis and regeneration, and have beneficial effects on microRNA profiles. They have proven to be anti-remodeling in numerous animal studies, mostly in rodents; a specific action on the border zone has been described. Studies in humans with DIPTA have been in conclusion. Remodeling can be defined as an increase of ≥20 % of the end-diastolic or end-systolic volume, together with a return to the fetal phenotype. An overview of animal and clinical studies is given.

Keywords: Cardiac remodeling; DIPTA; Myocardial infarction; Thyroid hormones; Thyroid receptors.

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