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. 2016 May 3;11(5):e0154358.
doi: 10.1371/journal.pone.0154358. eCollection 2016.

Physical Activity and Sedentary Behavior in Metabolically Healthy versus Unhealthy Obese and Non-Obese Individuals - The Maastricht Study

Belle H de Rooij  1   2 , Julianne D van der Berg  1   2 , Carla J H van der Kallen  3   4 , Miranda T Schram  3   4 , Hans H C M Savelberg  5   6 , Nicolaas C Schaper  2   3   4 , Pieter C Dagnelie  2   4   7 , Ronald M A Henry  3   4 , Abraham A Kroon  3   4 , Coen D A Stehouwer  3   4 , Annemarie Koster  1   2
Affiliations

Physical Activity and Sedentary Behavior in Metabolically Healthy versus Unhealthy Obese and Non-Obese Individuals - The Maastricht Study

Belle H de Rooij et al. PLoS One. .

Abstract

Background: Both obesity and the metabolic syndrome are associated with increased risk of cardiovascular diseases and type 2 diabetes. Although both frequently occur together in the same individual, obesity and the metabolic syndrome can also develop independently from each other. The (patho)physiology of "metabolically healthy obese" (i.e. obese without metabolic syndrome) and "metabolically unhealthy non-obese" phenotypes (i.e. non-obese with metabolic syndrome) is not fully understood, but physical activity and sedentary behavior may play a role.

Objective: To examine objectively measured physical activity and sedentary behavior across four groups: I) "metabolically healthy obese" (MHO); II) "metabolically unhealthy obese" (MUO); III)"metabolically healthy non-obese" (MHNO); and IV) "metabolically unhealthy non-obese" (MUNO).

Methods: Data were available from 2,449 men and women aged 40-75 years who participated in The Maastricht Study from 2010 to 2013. Participants were classified into the four groups according to obesity (BMI≥30kg/m2) and metabolic syndrome (ATPIII definition). Daily activity was measured for 7 days with the activPAL physical activity monitor and classified as time spent sitting, standing, and stepping.

Results: In our study population, 562 individuals were obese. 19.4% of the obese individuals and 72.7% of the non-obese individuals was metabolically healthy. After adjustments for age, sex, educational level, smoking, alcohol use, waking time, T2DM, history of CVD and mobility limitation, MHO (n = 107) spent, per day, more time stepping (118.2 versus 105.2 min; p<0.01) and less time sedentary (563.5 versus 593.0 min., p = 0.02) than MUO (n = 440). In parallel, MHNO (n = 1384) spent more time stepping (125.0 versus 115.4 min; p<0.01) and less time sedentary (553.3 versus 576.6 min., p<0.01) than MUNO (n = 518).

Conclusion: Overall, the metabolically healthy groups were less sedentary and more physically active than the metabolically unhealthy groups. Therefore, physical activity and sedentary time may partly explain the presence of the metabolic syndrome in obese as well as non-obese individuals.

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Conflict of interest statement

Competing Interests: This study received funding from Janssen-Cilag B.V, Novo Nordisk Farma B.V. and Sanofi-Aventis Netherlands B.V. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Figures

Fig 1
Fig 1. proportional sedentary, standing and stepping time (high and low intensity) per waking day, adjusted for age, sex, educational level, smoking, alcohol use, type 2 diabetes status, history of cardiovascular diseases and mobility limitation.
See this image and copyright information in PMC

References

    1. WHO (2014) Obesity and overweight. In: N°311 Fs, editor. Fact Sheets: World Health Organization.
    1. Grundy SM, Brewer HB Jr, Cleeman JI, Smith SC Jr, Lenfant C (2004) Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Arterioscler Thromb Vasc Biol 24: e13–18. - PubMed
    1. Wildman RP, Muntner P, Reynolds K, McGinn AP, Rajpathak S, et al. (2008) The obese without cardiometabolic risk factor clustering and the normal weight with cardiometabolic risk factor clustering: prevalence and correlates of 2 phenotypes among the US population (NHANES 1999–2004). Arch Intern Med 168: 1617–1624. 10.1001/archinte.168.15.1617 - DOI - PubMed
    1. Poelkens F, Eijsvogels TM, Brussee P, Verheggen RJ, Tack CJ, et al. (2014) Physical fitness can partly explain the metabolically healthy obese phenotype in women. Exp Clin Endocrinol Diabetes 122: 87–91. 10.1055/s-0033-1363686 - DOI - PubMed
    1. Phillips CM, Dillon C, Harrington JM, McCarthy VJ, Kearney PM, et al. (2013) Defining metabolically healthy obesity: role of dietary and lifestyle factors. PLoS One 8: e76188 10.1371/journal.pone.0076188 - DOI - PMC - PubMed