Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 Jun;17(6):365-72.
doi: 10.1038/nrg.2016.47. Epub 2016 May 3.

RNA modifications: what have we learned and where are we headed?

Michaela Frye  1 , Samie R Jaffrey  2 , Tao Pan  3 , Gideon Rechavi  4 , Tsutomu Suzuki  5
Affiliations
Review

RNA modifications: what have we learned and where are we headed?

Michaela Frye et al. Nat Rev Genet. 2016 Jun.

Abstract

Proper control of the transcriptome is key for diverse aspects of gene expression, cellular functions and development, and its disruption can result in disease. A rapidly accumulating wealth of studies are identifying and functionally characterizing diverse types of RNA base modifications in protein-coding and non-coding RNAs, which have energized the emerging field of 'epitranscriptomics'. In this Viewpoint article, five experts discuss our latest understanding of RNA modifications, including recommendations for best practices and visions for the future.

PubMed Disclaimer

References

    1. Nat Methods. 2015 Aug;12(8):767-72 - PubMed
    1. Cell Stem Cell. 2014 Dec 4;15(6):707-19 - PubMed
    1. Nat Struct Mol Biol. 2012 Sep;19(9):900-5 - PubMed
    1. Cell. 2012 Jun 22;149(7):1635-46 - PubMed
    1. Cell. 2013 Dec 5;155(6):1409-21 - PubMed

LinkOut - more resources