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Review
. 2016 Sep;73(17):3311-21.
doi: 10.1007/s00018-016-2229-7. Epub 2016 May 3.

Mesenchymal stem cell subpopulations: phenotype, property and therapeutic potential

Miaohua Mo  1   2 , Shan Wang  1   2 , Ying Zhou  1   2 , Hong Li  3 , Yaojiong Wu  4
Affiliations
Review

Mesenchymal stem cell subpopulations: phenotype, property and therapeutic potential

Miaohua Mo et al. Cell Mol Life Sci. 2016 Sep.

Abstract

Mesenchymal stem cells (MSC) are capable of differentiating into cells of multiple cell lineages and have potent paracrine effects. Due to their easy preparation and low immunogenicity, MSC have emerged as an extremely promising therapeutic agent in regenerative medicine for diverse diseases. However, MSC are heterogeneous with respect to phenotype and function in current isolation and cultivation regimes, which often lead to incomparable experimental results. In addition, there may be specific stem cell subpopulations with definite differentiation capacity toward certain lineages in addition to stem cells with multi-differentiation potential. Recent studies have identified several subsets of MSC which exhibit distinct features and biological activities, and enhanced therapeutic potentials for certain diseases. In this review, we give an overview of these subsets for their phenotypic, biological and functional properties.

Keywords: CD146; Cell surface markers; Heterogeneity; PDGFR; Stromal cells.

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