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. 2016 Apr;106(4):333-7.
doi: 10.5935/abc.20160052.

Network Meta-analysis to Synthesize Evidence for Decision Making in Cardiovascular Research

[Article in English, Portuguese]
Leonardo Roever  1 , Giuseppe Biondi-Zoccai  2
Affiliations

Network Meta-analysis to Synthesize Evidence for Decision Making in Cardiovascular Research

[Article in English, Portuguese]
Leonardo Roever et al. Arq Bras Cardiol. 2016 Apr.

Abstract

Clinical decision-making requires synthesis of evidence from literature reviews focused on a specific theme. Evidence synthesis is performed with qualitative assessments and systematic reviews of randomized clinical trials, typically covering statistical pooling with pairwise meta-analyses. These methods include adjusted indirect comparison meta-analysis, network meta-analysis, and mixed-treatment comparison. These tools allow synthesis of evidence and comparison of effectiveness in cardiovascular research.

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Conflict of interest statement

Potential Conflict of Interest

No potential conflict of interest relevant to this article was reported.

Figures

Figure 1
Figure 1
Evidence hierarchy of primary research and secondary research in cardiovascular medicine.
Figure 2
Figure 2
Conceptual framework moving from univariate meta-analysis (top left panel) to pairwise meta-analysis (top right panel), network meta-analysis (bottom left panel), and multivariate meta-analysis (bottom right panel). A, B, C, and D represent competing treatments for the same condition; continuous lines represent direct comparisons stemming from head-to-head randomized trials; dashed lines represent indirect comparisons; and different colors represent different endpoints of interest.
See this image and copyright information in PMC

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References

    1. Greco T, Biondi-Zoccai G, Saleh O, Pasin L, Cabrini L, Zangrillo A, et al. The attractiveness of network meta-analysis: a comprehensive systematic and narrative review. Heart Lung Vessel. 2015;7(2):133–142. - PMC - PubMed
    1. Biondi-Zoccai G, Abbate A, Benedetto U, Palmerini T, D'Ascenzo F, Frati G. Network meta-analysis for evidence synthesis: What is it and why is it posed to dominate cardiovascular decision making? Int J Cardiol. 2015;182:309–314. - PubMed
    1. Guyatt G, Meade MO, Cook DJ, Rennie D. Users' guides to the medical literature:a manual for evidence-based clinical practice. 3rd ed. New York: McGrawHill; 2014.
    1. Stolker JM, Spertus JA, Cohen DJ, Jones PG, Jain KK, Bamberger E, et al. Rethinking composite end points in clinical trials: insights from patients and trialists. Circulation. 2014;130(15):1254–1261. - PMC - PubMed
    1. Biondi-Zoccai G. Network meta-analysis:evidence synthesis with mixed treatment comparison. Hauppauge(NY): Science Publishers; 2014.