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. 2016 Apr;106(4):333-7.
doi: 10.5935/abc.20160052.

Network Meta-analysis to Synthesize Evidence for Decision Making in Cardiovascular Research

[Article in English, Portuguese]
Leonardo Roever  1 , Giuseppe Biondi-Zoccai  2
Affiliations

Network Meta-analysis to Synthesize Evidence for Decision Making in Cardiovascular Research

[Article in English, Portuguese]
Leonardo Roever et al. Arq Bras Cardiol. 2016 Apr.

Abstract

Clinical decision-making requires synthesis of evidence from literature reviews focused on a specific theme. Evidence synthesis is performed with qualitative assessments and systematic reviews of randomized clinical trials, typically covering statistical pooling with pairwise meta-analyses. These methods include adjusted indirect comparison meta-analysis, network meta-analysis, and mixed-treatment comparison. These tools allow synthesis of evidence and comparison of effectiveness in cardiovascular research.

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Conflict of interest statement

Potential Conflict of Interest

No potential conflict of interest relevant to this article was reported.

Figures

Figure 1
Figure 1
Evidence hierarchy of primary research and secondary research in cardiovascular medicine.
Figure 2
Figure 2
Conceptual framework moving from univariate meta-analysis (top left panel) to pairwise meta-analysis (top right panel), network meta-analysis (bottom left panel), and multivariate meta-analysis (bottom right panel). A, B, C, and D represent competing treatments for the same condition; continuous lines represent direct comparisons stemming from head-to-head randomized trials; dashed lines represent indirect comparisons; and different colors represent different endpoints of interest.
See this image and copyright information in PMC

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