Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Nov;44(5):1186-1196.
doi: 10.1002/jmri.25267. Epub 2016 May 3.

3T MRI investigation of cardiac left ventricular structure and function in a UK population: The tayside screening for the prevention of cardiac events (TASCFORCE) study

Stephen J Gandy  1   2 , Matthew Lambert  3 , Jill Belch  3 , Ian Cavin  2 , Elena Crowe  1 , Roberta Littleford  3 , Jennifer A MacFarlane  2 , Shona Z Matthew  3 , Patricia Martin  1 , R Stephen Nicholas  1   2 , Allan Struthers  3 , Frank Sullivan  4   5 , Shelley A Waugh  2 , Richard D White  1   6 , Jonathan R Weir-McCall  3 , J Graeme Houston  7   8
Affiliations

3T MRI investigation of cardiac left ventricular structure and function in a UK population: The tayside screening for the prevention of cardiac events (TASCFORCE) study

Stephen J Gandy et al. J Magn Reson Imaging. 2016 Nov.

Abstract

Purpose: To scan a volunteer population using 3.0T magnetic resonance imaging (MRI). MRI of the left ventricular (LV) structure and function in healthy volunteers has been reported extensively at 1.5T.

Materials and methods: A population of 1528 volunteers was scanned. A standardized approach was taken to acquire steady-state free precession (SSFP) LV data in the short-axis plane, and images were quantified using commercial software. Six observers undertook the segmentation analysis.

Results: Mean values (±standard deviation, SD) were: ejection fraction (EF) = 69 ± 6%, end diastolic volume index (EDVI) = 71 ± 13 ml/m2 , end systolic volume index (ESVI) = 22 ± 7 ml/m2 , stroke volume index (SVI) = 49 ± 8 ml/m2 , and LV mass index (LVMI) = 55 ± 12 g/m2 . The mean EF was slightly larger for females (69%) than for males (68%), but all other variables were smaller for females (EDVI 68v77 ml/m2 , ESVI 21v25 ml/m2 , SVI 46v52 ml/m2 , LVMI 49v64 g/m2 , all P < 0.05). The mean LV volume data mostly decreased with each age decade (EDVI males: -2.9 ± 1.3 ml/m2 , females: -3.1 ± 0.8 ml/m2 ; ESVI males: -1.3 ± 0.7 ml/m2 , females: -1.7 ± 0.5 ml/m2 ; SVI males: -1.7 ± 0.9 ml/m2 , females: -1.4 ± 0.6 ml/m2 ; LVMI males: -1.6 ± 1.1 g/m2 , females: -0.2 ± 0.6 g/m2 ) but the mean EF was virtually stable in males (0.6 ± 0.6%) and rose slightly in females (1.2 ± 0.5%) with age.

Conclusion: LV reference ranges are provided in this population-based MR study at 3.0T. The variables are similar to those described at 1.5T, including variations with age and gender. These data may help to support future population-based MR research studies that involve the use of 3.0T MRI scanners. J. Magn. Reson. Imaging 2016;44:1186-1196.

Keywords: 3.0T; MRI; cardiac; left ventricle; population.

PubMed Disclaimer

Figures

Figure 1
Figure 1
A plot of mean ejection fraction (EF), end‐diastolic volume (EDV), end‐systolic volume (ESV), stroke volume (SV), and left ventricular mass (LVM) showing the change of each variable with age in males and females for cohorts in the age ranges 50–59 years (50s), 60–69 years (60s) and over 70 years (≥70s), relative to the baseline 40–49 years (40s) cohort.
Figure 2
Figure 2
Variation in mean left ventricular mass index (LVMI; ± SD) between the different observers who participated in the data analysis. Of note is that observer 2 consistently derived the largest LVMI values and observer 4 consistently derived the smallest LVMI values. These data do not represent “true interobserver variation” since each study cohort was different for each observer. However, by using the LVMI and stratifying by gender, the component of the variation due to different cohort sizes and gender ratios has been minimized.
See this image and copyright information in PMC

References

    1. Alfakih K, Plein S, Thiele H, Jones T, Ridgway JP, Sivananthan MU. Normal human left and right ventricular dimensions for MRI as assessed by turbo gradient echo and steady‐state free precession imaging sequences. J Magn Reson Imaging JMRI 2003;17:323–329. - PubMed
    1. Hudsmith LE, Petersen SE, Francis JM, Robson MD, Neubauer S. Normal human left and right ventricular and left atrial dimensions using steady state free precession magnetic resonance imaging. J Cardiovasc Magn Reson 2005;7:775–782. - PubMed
    1. Maciera AM, Prasad SK, Khan M, Pennell DJ. Normalized Left ventricular systolic and diastolic function by steady state free precession cardiovascular magnetic resonance. J Cardiovasc Magn Reson 2006;8:417–426. - PubMed
    1. Yeon SB, Salton CJ, Gona P, et al. Impact of age, sex, and indexation method on MR left ventricular reference values in the Framingham Heart Study offspring cohort. J Magn Reson Imaging 2015;41:1038–1045. - PMC - PubMed
    1. Chung AK, Das SR, Leonard D, et al. Women have higher left ventricular ejection fractions than men independent of differences in left ventricular volume: the Dallas Heart Study. Circulation 2006;113:1597–1604. - PubMed

Publication types

MeSH terms