Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Apr 19:12:617-22.
doi: 10.2147/TCRM.S100557. eCollection 2016.

Are the blood groups of women with preeclampsia a risk factor for the development of hypertension postpartum?

Deniz Avci  1 , Hatice Karagoz  2 , Ozerhan Ozer  1 , Kubra Esmeray  1 , Kadir Bulut  1 , Fatma Aykas  1 , Ali Cetinkaya  1 , Emine Uslu  1 , Samet Karahan  1 , Mustafa Basak  1 , Abdulsamet Erden  1
Affiliations

Are the blood groups of women with preeclampsia a risk factor for the development of hypertension postpartum?

Deniz Avci et al. Ther Clin Risk Manag. .

Abstract

Introduction: Preeclampsia (PE) is a pregnancy-related disorder characterized by hypertension (HT) and proteinuria noticeable after 20 weeks of gestation. PE is now considered as a cardiovascular disease risk factor and a number of studies have shown that experiencing PE increases the prevalence of various cardiovascular risk factors, such as metabolic syndrome and HT. In this study, we aimed to investigate any possible relationship between the ABO/Rh blood group system and PE in Turkey. In the second part of the study, we examined the relationship between the ABO blood group system and development of HT after PE.

Patients and methods: A total of 250 patients with PE from Kayseri Training and Research Hospital between 2002 and 2012 were included in the study. Patients were classified according to blood groups (A, B, AB, and O) and Rh status (+/-).

Results: There was a significant difference between the patients with PE and the control group in terms of distribution of ABO blood groups and the percentage of group AB was found to be higher in patients with PE compared to the control group (P=0.029). The risk of developing PE was significantly higher in group AB than other blood groups (P=0.006). The risk of developing HT after PE was significantly higher in group O than other blood groups (P=0.004).

Discussion: In this study, we found that the patients with blood group AB have a higher risk for PE. The patients with PE of blood group O are at high risk of developing HT, and Rh factor was identified as another risk at this point and these patients should be closely followed postpartum.

Keywords: ABO blood groups; Rh factor; hypertension; postpartum; preeclampsia; pregnancy; proteinuria.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Petla LT, Chikkala R, Ratnakar KS, Kodati V, Sritharan V. Biomarkers for the management of pre-eclampsia in pregnant women. Indian J Med Res. 2013;138(1):60–67. - PMC - PubMed
    1. Uzan J, Carbonnel M, Piconne O, Asmar R, Ayoubi JM. Pre-eclampsia: pathophysiology, diagnosis, and management. Vasc Health Risk Manag. 2011;7:467–474. - PMC - PubMed
    1. Duley L. The global impact of pre-eclampsia and eclampsia. Semin Perinatol. 2009;33(3):130–137. - PubMed
    1. Williams PJ, Pipkin FB. The genetics of pre-eclampsia and other hypertensive disorders of pregnancy. Best Pract Res Clin Obset Gynaecol. 2011;25(4–4):405–417. - PMC - PubMed
    1. Aykas F, Solak Y, Erden A, et al. Persistence of cardiovascular risk factors in women with previous preeclampsia: a long-term follow-up study. J Investig Med. 2015;63(4):641–645. - PubMed

LinkOut - more resources