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Case Reports
. 2016 Mar 22:18:35-6.
doi: 10.1016/j.rmcr.2016.03.006. eCollection 2016.

Sulfasalazine: A rare cause of acute eosinophilic pneumonia

P Nadarajan  1 , A Fabre  2 , E Kelly  1
Affiliations
Case Reports

Sulfasalazine: A rare cause of acute eosinophilic pneumonia

P Nadarajan et al. Respir Med Case Rep. .

Abstract

Sulfasalazine is a compound of 5-aminosalicylic acid (5-ASA) and sulfapyridine joined by an azo bond. It is a widely used drug in the treatment of chronic inflammatory bowel disease. Fatal toxicity of sulfasalazine arises from its effects on the bone marrow and the resulting blood dyscrasias. Pulmonary toxicity from sulfasalazine is a rather rare finding. Here, we present the case of a patient who developed acute eosinophilic pneumonia with sulfasalazine use.

Keywords: ASA, Aminosalicylic Acid; BAL, Bronchoalveolar Lavage; CRP, C-reactive protein; Drug induced lung disease; Eosinophilic pneumonia; Interstitial lung disease; MGG, May-Grunwald-Giemsa; TNF-α, Tumour necrosis factor alpha.

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Figures

Fig. 1
Fig. 1
Chest radiograph on admission.
Fig. 2
Fig. 2
Bronchoalveolar lavage cytology showing eosinophils (MGG stain).
Fig. 3
Fig. 3
Chest radiograph 2 weeks after treatment with oral corticosteroids.
See this image and copyright information in PMC

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