Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2016 May 1;40(3):219-24.
doi: 10.7399/fh.2016.40.3.10439.

Pre-exposure prophylaxis for the prevention of HIV infection: a new prevention paradigm?

Javier Sánchez-Rubio Ferrández  1 , José Manuel Martínez Sesmero  2
Affiliations
Comment

Pre-exposure prophylaxis for the prevention of HIV infection: a new prevention paradigm?

Javier Sánchez-Rubio Ferrández et al. Farm Hosp. .

Abstract
in English, Spanish

Pre-exposure prophylaxis" (PrEP) has been recently developed as a prevention strategy which involves the administration of drugs to non-infected individuals who present high exposure or susceptibility to HIV. Although this use is not approved in our country, several guidelines recommend PrEP as a prevention option in adult MSM, heterosexual men and women, and users of parenteral drugs at risk of acquiring the infection. This article presents the characteristics that an ideal agent to be used as PrEP should meet, recent efficacy published data and barriers for the implementation of this new strategy. On the other hand, the role of hospital pharmacists will be discussed.

La “profilaxis pre-exposición (PrEP)” ha sido recientemente desarrollada como una estrategia de prevención que consiste en la administración de medicamentos a los individuos no infectados que presentan una alta exposición y susceptibilidad al VIH. Aunque este uso no está aprobado en nuestro país, varias guías recomiendan la PrEP como una opción de prevención en HSH adultos, hombres y mujeres heterosexuales, y los usuarios de drogas parenterales en riesgo de adquirir la infección. Este artículo presenta las características que un agente ideal para ser utilizado como profilaxis pre-exposición debe cumplir, los datos de eficacia recientemente publicados y las barreras para la implementación de esta nueva estrategia. Por otra parte, se discute el papel de los farmacéuticos del hospital en la posible implantación de esta estrategia en el futuro.

PubMed Disclaimer

Comment on

  • Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women.
    Abdool Karim Q, Abdool Karim SS, Frohlich JA, Grobler AC, Baxter C, Mansoor LE, Kharsany AB, Sibeko S, Mlisana KP, Omar Z, Gengiah TN, Maarschalk S, Arulappan N, Mlotshwa M, Morris L, Taylor D; CAPRISA 004 Trial Group. Abdool Karim Q, et al. Science. 2010 Sep 3;329(5996):1168-74. doi: 10.1126/science.1193748. Epub 2010 Jul 19. Science. 2010. PMID: 20643915 Free PMC article. Clinical Trial.
  • Tenofovir-based preexposure prophylaxis for HIV infection among African women.
    Marrazzo JM, Ramjee G, Richardson BA, Gomez K, Mgodi N, Nair G, Palanee T, Nakabiito C, van der Straten A, Noguchi L, Hendrix CW, Dai JY, Ganesh S, Mkhize B, Taljaard M, Parikh UM, Piper J, Mâsse B, Grossman C, Rooney J, Schwartz JL, Watts H, Marzinke MA, Hillier SL, McGowan IM, Chirenje ZM; VOICE Study Team. Marrazzo JM, et al. N Engl J Med. 2015 Feb 5;372(6):509-18. doi: 10.1056/NEJMoa1402269. N Engl J Med. 2015. PMID: 25651245 Free PMC article. Clinical Trial.

LinkOut - more resources