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Randomized Controlled Trial
. 2016 May;37(5):527-32.
doi: 10.15537/smj.2016.5.15083.

Comparison of paracetamol and fentanyl for pain relief during and after suction termination

Ayça S Şahin  1 , Aykan Gülleroğlu, Melike K Toker, Ayse G Karabay, Ozal Adıyeke, Yavuz Demiraran
Affiliations
Randomized Controlled Trial

Comparison of paracetamol and fentanyl for pain relief during and after suction termination

Ayça S Şahin et al. Saudi Med J. 2016 May.

Abstract

Objectives: To compare the combination of paracetamol (20 mg/kg) and propofol to fentanyl (1 µg/kg) and propofol in terms of providing adequate analgesia and a comparable recovery profile in suction termination procedures.

Methods: This is a prospective, randomized clinical study in which we obtained informed consents from 146 women (fentanyl group: 76 [52.1%], paracetamol group: 70 [47.9%]) who were scheduled for suction curettage at the Istanbul Kanuni Sultan Suleyman Education and Training Hospital, Istanbul, Turkey in January 2015. Patients were randomly allocated into a fentanyl group or a paracetamol group. Visual analogue scores, modified Aldrete scores, and hemodynamic parameters were recorded during and after the surgical procedure. A record was also maintained of any adverse events.

Results: When the modified Aldrete scores at 60 minutes, systolic pressures at 0 minutes, oxygen saturation at 10, 15, 20 minutes, diastolic blood pressure at 10, 15, 20 minutes, heart rates, and visual analogue scores were compared, there was no significant difference between groups (p greater than 0.05). In the fentanyl group, systolic blood pressures at 5, 10, 15, 20 minutes and diastolic blood pressure at 5 minutes and oxygen saturation at 5 minutes were significantly lower (p less than 0.05).

Conclusion: Our study demonstrates that the analgesic properties and recovery profiles of intravenous paracetamol is as effective as fentanyl when used in suction termination procedures. Further larger studies are still required.

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Figures

Figure 1
Figure 1
Flow diagram of 146 women who were scheduled for suction curettage. SBP - systolic blood pressure, DBP - diastolic blood pressure, HR - heart rates, VAS - visual analogue scale
Figure 2
Figure 2
Heart rates of 146 women who were scheduled for suction curettage. min- minutes
Figure 3
Figure 3
Systolic blood pressures of 146 women who were scheduled for suction curettage. min- minutes
Figure 4
Figure 4
Diastolic blood pressures of 146 women who were scheduled for suction curettage. min- minutes
Figure 5
Figure 5
Oxygen saturation (SpO2) of 146 women who were scheduled for suction curettage. min- minutes
See this image and copyright information in PMC

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