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Editorial
. 2016 May 17;113(20):5465-6.
doi: 10.1073/pnas.1605215113. Epub 2016 May 4.

Dendrites actively restrain axon outgrowth and regeneration

Michael M Francis  1 , Marc R Freeman  2
Affiliations
Editorial

Dendrites actively restrain axon outgrowth and regeneration

Michael M Francis et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Dendritic control of axon growth and regrowth. Dendrites actively suppress ectopic sprouting, even in wild-type uninjured axons, through the Dlk-independent EGL-19/TAX2,4/UNC-43/SAX-1 pathway. In wild-type animals, Dlk activity is sufficient to drive axon regrowth after axotomy (red axon), even in the presence of this inhibitory pathway, but regeneration is completely suppressed in dlk−/− animals because of inhibitory signals from dendrites. Cutting dendrites in the dlk−/− background or eliminating components of the EGL-19/TAX2,4/UNC-43/SAX-1 pathway relieves this antigrowth signal and results in Dlk-independent axonal outgrowth.
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Comment in

References

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