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Review
. 2016 Jul 1;311(1):F63-5.
doi: 10.1152/ajprenal.00245.2016. Epub 2016 May 4.

Novel therapeutic approaches for chronic kidney disease due to glomerular disorders

Maria Del Nogal-Avila  1 , Hector Donoro-Blazquez  1 , Manish K Saha  1 , Caroline B Marshall  1 , Lionel C Clement  1 , Camille E A Macé  1 , Sumant S Chugh  2
Affiliations
Review

Novel therapeutic approaches for chronic kidney disease due to glomerular disorders

Maria Del Nogal-Avila et al. Am J Physiol Renal Physiol. .

Abstract

Improved understanding of glomerular disease mechanisms over the past decade has led to the emergence of new and targeted therapeutic strategies for chronic kidney disease (CKD). Most promising among these are the administration of recombinant mutated human angiopoietin-like 4, sialic acid-related sugars that induce sialylation in vivo, compounds related to Bis-T-23, and immune depletion of the soluble urokinase receptor from the circulation. Taking these therapeutic strategies into clinical trials will be the first step away from repurposed and relatively toxic drugs currently used for treating kidney disease.

Keywords: chronic kidney disease; drugs; proteinuria.

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References

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