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. 1989 May 15;43(5):781-3.
doi: 10.1002/ijc.2910430506.

Centchroman--a non-steroidal anti-cancer agent for advanced breast cancer: phase-II study

N C Misra  1 , P K Nigam, R Gupta, A K Agarwal, V P Kamboj
Affiliations

Centchroman--a non-steroidal anti-cancer agent for advanced breast cancer: phase-II study

N C Misra et al. Int J Cancer. .

Abstract

Treatment with Centchroman (3,4-trans-2,2-dimethyl-3-phenyl-4-p-(beta-pyrrolidinoethoxy) phenyl-7-methoxy chroman) has been evaluated in 4 male and 75 female patients with advanced breast cancer. The overall response rate, including both male and female cases, was 40.5%. Among the female patients, the overall response rate was 38.7%. The median duration of response was 6 months. One of the 4 male patients showed a complete response and 2 showed partial responses. The responses were more marked for bone, pulmonary, soft tissue, skin and lymph-node metastases than for liver metastases.

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