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Comment
. 2016 Jun 2;17(6):592-4.
doi: 10.1080/15384047.2016.1178883. Epub 2016 May 5.

YAP controls transcriptional elongation through CKD9 recruitment for proximal pause release: "Hippo-thetical", new therapeutic targets?

Fiorina Kyritsi  1 , Douglas K Price  1 , William D Figg  1
Affiliations
Comment

YAP controls transcriptional elongation through CKD9 recruitment for proximal pause release: "Hippo-thetical", new therapeutic targets?

Fiorina Kyritsi et al. Cancer Biol Ther. .

Abstract

The Hippo-YAP signaling pathway has been established as a crucial regulator of tissue growth and tumorigenesis but the mechanism for transcriptional control remains unclear. In their study, Galli et al. show that YAP/TAZ binding is restricted to a small number of gene enhancers and that YAP/TAZ regulates transcriptional elongation by recruiting the Mediator complex.

Keywords: Hippo/YAP pathway; YAP-bound regulatory elements; mediator complex; transcriptional elongation; tumorigenesis.

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References

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